Biomarker in the detection of fumonisin toxicosis in pigs

Abstract

The sphinganine to sphingosine ratio (Sa/So) after oral administration of 50 mg fumonisin B₁/animal/day for 10 days and after a 10-day elimination period was studied in weaned barrows. At the beginning of the experiment, then after a 10-day period of the toxin feeding and on the 10^th day after the end of the toxin feeding blood samples were taken and from those the Sa/So ratio was determined. Directly after the 10-day period of the toxin feeding the Sa/So ratio was 6.2-fold higher, as compared to control group and it decreased only in a slight extent even after the 10-day elimination period. Based on the results, presumably the restitution in the Sa-So parameters is more slower than the elimination of fumonisin from the organism.