Protective effect of vitamins and epicatechin on cadmium toxicity in rats
Kulcsszavak:
kadmiummérgezés, N-acetil-β-D-glukozaminidáz, alanin-amino-peptidáz, Cvitamin, E-vitamin, epikatechinAbsztrakt
A kadmium az egyik legmérgezőbb nehézfém. Jelentős környezeti és foglalkozási kontaminációja egészségügyi kockázatot jelent mind az emberi mind az állati szervezetekre. A kadmium az emberi szervezetben felhalmozódik, és potenciális rákkeltő hatása van. Az antioxidánsok, mint a C-vitamin, E-vitamin és epikatechin (zöld tea kivonat) fontos szereppel bírnak a kadmiummérgezés során jelentkező oxidatív stressz okozta károsodások megelőzésében. Vizsgálatunkban a C-vitamin, E-vitamin és az epikatechin védőhatását tanulmányoztuk a kadmium indukálta oxidatív stresszre. Patkányokon végeztük el a vizsgálatot, amelyeket hetente 5 napon át, 21 napig kezeltünk kadmiummal. Biomarkerek segítségével mértük a kadmiummérgezés hatására jelentkező veseelégtelenséget és a lipid peroxidációt. A C-vitamin, az E-vitamin és epikatechin javította a kadmiumos kezelés hatására lecsökkent szérum alanin-amino-peptidáz (AAP) és a N-acetil-β-D-glukozaminidaz (NAG) szinteket. Az oxidatív stressz biomarkerek közül a szérum glutathion peroxidáz (GPx) szintet a kadmiumos kezelés lecsökkentette, de az alkalmazott antioxidánsok a vizsgált enzim aktivitásának mértékét fokozták. Az eredményeink azt támasztották alá, hogy a C-vitamin, E-vitamin és epikatechin (zöld tea kivonat) bizonyos fokú védelmet biztosítanak a kadmiummérgezés okozta oxidatív stresszel szemben.
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