Closed-chest occlusion of the left anterior descending artery in swine infarction model: Review

Dénes Kőrösi; András Vorobcsuk; Dániel Fajtai; Ottó Tátrai; Emőke Bodor; Rita Garamvölgyi

doi:10.31914/aak.3423

Authors

Dénes Kőrösi Hungarian University of Agriculture and Life Sciences, Doctoral School in Animal Science, 7400 Kaposvár, Guba Sándor str. 40., Hungary. Corresponding author, e-mail: korosidenes@gmail.com
András Vorobcsuk Kaposi Mór Teaching Hospital, Department of Cardiology, 7400 Kaposvár, Tallián Gy. str. 20-32., Hungary
Dániel Fajtai 3Medicopus Health Care Services Public Benefit Nonprofit Ltd., 7400 Kaposvár, Guba Sándor str. 40.
Ottó Tátrai Kaposi Mór Teaching Hospital, Department of Cardiology, 7400 Kaposvár, Tallián Gy. str. 20-32., Hungary
Emőke Bodor Kaposi Moritz Teaching Hospital, Department of Cardiology, 7400 Kaposvár, Tallián Gy. str. 20-32., Hungary
Rita Garamvölgyi Auvet Pharma Co. 7400 Kaposvár, Dombóvári str. 3.

DOI:

https://doi.org/10.31914/aak.3423

Keywords:

myocardial infarction in pigs, translational research, coronary occlusion, large animal modeling

Abstract

Pigs have played a significant role in biological and medical research for many years. In the case of non-rodent models, pigs are the primary choices as experimental animals in the cardiovascular studies. Accumulating data indicate that the closed-chest coronary balloon-occlusion technique is one of the most successful method for creating ischemic heart failure (HF). However, consistent and thoroughly characterized large animal models of HF are a critical translational tool for drug development and toxicology. The knowledge of the different catheterization protocols is crucial to ensure a suitable animal model which can serve as a human-related preclinical validation process. Therefore it is essential to follow an optimized and standardized experimental protocol on a homogenous animal population, which help to obtain reliable and useful data for the translational large animal research programs.

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