Closed-chest occlusion of the left anterior descending artery in swine infarction model: Review

Dénes Kőrösi; András Vorobcsuk; Dániel Fajtai; Ottó Tátrai; Emőke Bodor; Rita Garamvölgyi

doi:10.31914/aak.3423

Szerzők

Kőrösi Dénes Magyar Agrár és Élettudományi Egyetem, 7400 Kaposvár, Guba Sándor str. 40., Levelezőszerző, e-mail: korosidenes@gmail.com
Vorobcsuk András Kaposi Mór Oktató Kórház Kardiológiai Osztály, 7400 Kaposvár, Tallián Gy. utca 20-32.
Fajtai Dániel Medicopus Nonprofit Kft. 7400 Kaposvár, Guba Sándor utca 40.
Tátrai Ottó Kaposi Mór Oktató Kórház Kardiológiai Osztály, 7400 Kaposvár, Tallián Gy. utca 20-32.
Bodor Emőke Kaposi Mór Oktató Kórház Kardiológiai Osztály, 7400 Kaposvár, Tallián Gy. utca 20-32.
Garamvölgyi Rita Auvet Pharma Kft. 7400 Kaposvár, Dombóvári út 3.

DOI:

https://doi.org/10.31914/aak.3423

Kulcsszavak:

myocardial infarction in pig, translational research, coronary occlusion, large animal model

Absztrakt

Pigs have played a significant role in biological and medical research for many years. In the case of non-rodent models, pigs are the primary choices as experimental animals in the cardiovascular studies. Accumulating data indicate that the closed-chest coronary balloon-occlusion technique is one of the most successful method for creating ischemic heart failure (HF). However, consistent and thoroughly characterized large animal models of HF are a critical translational tool for drug development and toxicology. The knowledge of the different catheterization protocols is crucial to ensure a suitable animal model which can serve as a human-related preclinical validation process. Therefore it is essential to follow an optimized and standardized experimental protocol on a homogenous animal population, which help to obtain reliable and useful data for the translational large animal research programs.

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