Detection of ochratoxin A from the blood and urine of human patients suffering from nephropathy

Authors

  • Melinda Kovács University of Kaposvár, Faculty of Acimal Science, Research Group of Animal Breeding and Animal Hygiene, H-7400 Kaposvár, Guba S. u. 40.
  • József Sámik EuroCare Dialysis Centre no. 4, H-7400 Kaposvár, Tallián Gy. u. 20–34.
  • Béla Fazekas Veterinary Institute of Debrecen, H-4031 Debrecen, Bornemissza u. 3–7.
  • Zsuzsanna Lelovics University of Kaposvár, College Faculty of Pedagogy, H-7400 Kaposvár, Bajcsy-Zs. u. 10.
  • Roland Pósa University of Kaposvár, Faculty of Acimal Science, Research Group of Animal Breeding and Animal Hygiene, H-7400 Kaposvár, Guba S. u. 40.
  • András Bónai University of Kaposvár, Faculty of Acimal Science, Research Group of Animal Breeding and Animal Hygiene, H-7400 Kaposvár, Guba S. u. 40.
  • Ferenc Kovács University of Kaposvár, Faculty of Acimal Science, Research Group of Animal Breeding and Animal Hygiene, H-7400 Kaposvár, Guba S. u. 40.
  • Péter Horn University of Kaposvár, Faculty of Acimal Science, Research Group of Animal Breeding and Animal Hygiene, H-7400 Kaposvár, Guba S. u. 40.

Keywords:

ochratoxin A, blood and urine samples, nephropathy

Abstract

The authors determined the concentration of ochratoxin A (OTA) in 50 blood and 28 urine samples of human patients suffering from renal diseases (chronic glomerulo- and pyelonephritis, essential hypertension, renal cirrhosis, neoplastic and cystic changes) in Hungary. Forty-one out of the 50 serum samples assayed (82%) were found to contain OTA in a mean concentration of 0.33 ng/ml (range: 0.21–1.23 ng/ml). No significant differences were found in toxin content between the different age and sex groups studied. The proportion of the urine samples in which OTA could be detected (n = 28) was 57%, the mean OTA concentration was 0.007 ng/ml (range: 0.006–0.012 ng/ml), and OTA concentration was lower than 0.01 ng/ml in the majority of samples. Incidence was much more common in female patients (86%), while 52% of the urine samples collected from male patients were negative. The OTA content of blood and urine samples did not differ significantly from the values measured in our earlier study in healthy humans and from the data reported in the literature. No significant correlation was found between the type of kidney disorders and the OTA content of blood and urine samples.

Author Biography

  • Melinda Kovács, University of Kaposvár, Faculty of Acimal Science, Research Group of Animal Breeding and Animal Hygiene, H-7400 Kaposvár, Guba S. u. 40.

    corresponding author
    melinda@mail.atk.u-kaposvar.hu

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Published

2007-02-15

Issue

Vol. 11 No. 1 (2007): Acta Agraria Kaposváriensis

Section

Articles

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Copyright (c) 2007 Kovács Melinda, Sámik József, Fazekas Béla, Lelovics Zsuzsanna, Pósa Roland, Bónai András, Kovács Ferenc, Horn Péter

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This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

How to Cite

Kovács, M., Sámik, J., Fazekas, B., Lelovics, Z., Pósa, R., Bónai, A., Kovács, F., & Horn, P. (2007). Detection of ochratoxin A from the blood and urine of human patients suffering from nephropathy. Acta Agraria Kaposváriensis, 11(1), 1-8. https://journal.uni-mate.hu/index.php/aak/article/view/1820

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