Biomarker in the detection of fumonisin toxicosis in pigs
Keywords:
sphinganine, sphingosine, fumonisin, biomarker, pigAbstract
The sphinganine to sphingosine ratio (Sa/So) after oral administration of 50 mg fumonisin B1/animal/day for 10 days and after a 10-day elimination period was studied in weaned barrows. At the beginning of the experiment, then after a 10-day period of the toxin feeding and on the 10th day after the end of the toxin feeding blood samples were taken and from those the Sa/So ratio was determined. Directly after the 10-day period of the toxin feeding the Sa/So ratio was 6.2-fold higher, as compared to control group and it decreased only in a slight extent even after the 10-day elimination period. Based on the results, presumably the restitution in the Sa-So parameters is more slower than the elimination of fumonisin from the organism.
References
Bezuidenhout, S. C., Gelderblom, W. C. A., Gorst-Allman, C. P., Horak, R. M., Marasas, W. F. O., Spiteller, G. Vleggaar, R. (1988). Structure elucidation of the fumonisins, mycotoxins from Fusarium moniliforme. J. Chem. Soc. Chem. Commun. 11. 743–745. https://doi.org/10.1039/c39880000743
Bermudez A. J., Ledoux, D. R., Rottinghaus, G. E. (1995). Effects of Fusarium moniliforme culture material containing known levels of fumonisin B1 in ducklings. Avian Dis., 39(4), 879–886. https://doi.org/10.2307/1592427
Castegnaro, M., Garren, L., Gaucher, I., Wild, C. P. (1996). Development of a new method for the analysis of sphinganine and sphingosine in urine and tissues. Nat. Toxins. 4(6), 284–90. https://doi.org/10.1002/(SICI)(1996)4:6<284::AID-NT6>3.0.CO;2-Z
Castegnaro, M., Garren, L., Galendo, D., Gelderblom, W. C. A., Chelule, P., Dutton, M. F., Wild, C. P. (1998). Analytical method for the determination of sphinganine and sphingosine in serum as a potential biomarker for fumonisin exposure. J. Chromatogr. B 720(1–2), 15–24. https://doi.org/10.1016/S0378-4347(98)00446-0
Delongchamp, R. R., Young, J. F. (2001). Tissue sphinganine as a biomarker of fumonisin-induced apoptosis. Food Addit. Contam., 18(3), 255–261. https://doi.org/10.1080/02652030118953
Enongene, E. N., Sharma, R. P., Voss, K. A. Riley, R. T. (2000). Subcutaneous fumonisin administration disrupts sphingolipid metabolism in mouse digestive epithelia, liver, and kidney. Food Chem. Toxicol., 38. 793–799.
Fazekas, B. (1998). Fumonisin B1 and fusariotoxin contamination of corn and fumonisin mycotoxicoses [PhD thesis]. Georgikon Faculty of Agriculture of the Pannon University of Agricultural Sciences. Available from: University of Kaposvár. 1–160.
Gelderblom, W. C. A., Jaskiewicz, K., Marasas, W. F. O., Thiel, P. G., Horak, M. J., Vleggaar, R. Kriek, N. P. J. (1988). Fumonisins-novel mycotoxins with cancer promoting activity produced by Fusarium moniliforme. Appl. Environ. Microbiol., 54(7), 1806–1811. https://doi.org/10.1128/aem.54.7.1806-1811.1988
Gelderblom, W. C. A., Kriek, N. P. J., Marasas, W. F. O. Thiel, P. G. (1991). Toxicity and carcinogenicity of the Fusarium moniliforme metabolite, fumonisin BB1, in rats. Carcinogenesis. 12(7), 1247–1251. https://doi.org/10.1093/carcin/12.7.1247
Gumprecht, L. A., Beasley, V. R., Weigel, R. M., Parker, H. M., Tumbleson, M. E., Bacon, C. W., Meredith, F. I., Haschek, W. M. (1998). Development of fumonisin-induced hepatotoxicity and pulmonary edema in orally dosed swine: Morphological and biochemical alterations. Toxicol. Pathol., 26(6), 777–788. https://doi.org/10.1177/019262339802600610
Harrison, L. R., Colvin, B. M., Green, J. T., Newman, L. E., Cole, J. R. (1990). Pulmonary edema and hydrothorax in swine produced by fumonisin B1, a toxic metabolite of Fusarium moniliforme. J. Vet. Diagn. Invest., 2(3), 217–221. https://doi.org/10.1177/104063879000200312
International Agency for Research on Cancer Fumonisin B1 (1993). IARC Monographs on the Evaluation of Carcinogenic Risks to Humans: Some Traditional Medicines, Some Mycotoxins, Naphthalene and Styrene. IARC. 82. 301–366.
Kellerman, T. S., Marasas, W. F. O., Thiel, P. G., Gelderblom, W. C. A., Cawood, M. Coetzer, J. A. W. (1990). Leukoencephalomalacia in two horses induced by oral dosing of fumonisin B1. Onderstepoort. J. Vet. Res., 57. 269–275.
Merrill, A. H. Jr., Sweeley, C. C. (1996). Sphingolipids: metabolism and cell signaling. In: Biochemistry of Lipids, Lipoproteins and Membranes (Eds.: Vance, D. E., Vance, J. E.). New York : Elsevier. 43–73.
Plattner, R. D., Norred, W. P., Bacon, C. W., Voss, K. A., Peterson, R., Shackelford, D. D. Weisleder, D. (1990). A method of detection of fumonisin in corn samples associated with field cases of equine leukoencephalomalacia. Mycologia. 82(6), 698–702. https://doi.org/10.1080/00275514.1990.12025950
Prelusky, D. B., Miller, J. D., Trenholm, H. L. (1996). Disposition of 14C-derived residues in tissues of pigs fed radiolabelled fumonisin-B1. Food Add. Cont., 13(2), 155–162. https://doi.org/10.1080/02652039609374393
Riley, R. T., An, N. H., Showker, J. L., Yoo, H. S., Norred, W. P., Chamberlain, W. J., Wang, E., Merrill, A. H., Motelin, G., Beasley, V. R., Haschek, W. M. (1993). Alteration of Tissue and Serum Sphinganine to Sphingosine Ratio: An Early Biomarker of Exposure to Fumonisin-Containing Feeds in Pigs. Toxicology and Applied Pharmacology. 118(1), 105–112. https://doi.org/10.1006/taap.1993.1015
Riley, R. T., Wang, E., Merrill, A. H. Jr. (1994). Liquid chromatographic determination of sphinganine and sphingosine: Use of the free sphinganine-to-sphingosine ratio as a biomarker for consumption of fumonisins. J. Assoc. Off Anal. Chem. Int., 77(2), 533–540. https://doi.org/10.1093/jaoac/77.2.533
Ross, P. F., Nelson, P. E., Richard, J. L., Osweiler, G. D., Rice, L. G., Plattner, R. D. Wilson, T. M. (1990). Production of fumonisins by Fusarium moniliforme and Fusarium proliferatum isolates associated with equine leukoencephalomalacia and pulmonary edema syndrome in swine. Appl. Environ. Microbiol., 56(10), 3225–3226. https://doi.org/10.1128/aem.56.10.3225-3226.1990
Rotter, B. A., Thomson, B. K., Prelusky, D. B., Trenholm, H. L., Stewart, B., Miller, J. D., Savard, M. E. (1996). Response of growing swine to dietary exposure to pure fumonisin-B1 during an eight-week period: growth and clinical parameters. Natural Toxins. 4(1), 42–50. https://doi.org/10.1002/19960401NT6
Shephard, G. S., Sydenham, E. W., Thiel, P. G. Gelderblom, W. C. A. (1990). Quantitative determination of fumonisins B1 and B2 by high-performance liquid chromatography with fluorescence detection. J. Liq. Chromatogr., 13(10), 2077–2087. https://doi.org/10.1080/01483919008049014
SPSS Inc 1996. SPSS for Windows, Version 7.5, Chicago, IL
Sydenham, E. W., Thiel, P. G., Marasas, W. F. O., Shephard, G. S., Van Schalkwyk, D. J. Koch, K. R. (1990). Natural occurrence of some Fusarium mycotoxins in corn from low and high esophageal cancer prevalence areas of the Transkei, southern Africa. J. Agric. Food Chem., 38(10), 1900–1903. https://doi.org/10.1021/jf00100a004
World Health Organization (2002). Evaluation of Certain Mycotoxins in Food. Fifty-sixth Report of the Joint FAO/WHO Expert Committee on Food Additives (JECFA). WHO Technical Report. 906. 16–27.
Downloads
Published
Issue
Section
License
Copyright (c) 2006 Kametler László, Fodor Judit, Kovács Melinda, Horn Péter

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

