Transzlációhoz kapcsolt mRNS minőségellenőrző rendszerek szerepének áttekintése normál és patogénekkel szembeni működés során
Keywords:
nonsense-mediated decay, non-stop decay, no-go decay, translation-coupled quality control, pathogen defense mechanismsAbstract
In eukaryotes various quality control (QC) mechanisms operate to maintain the proper biochemical reactions that are necessary for life. A subset of them consists the translationcoupled quality control mechanisms. These systems – namely nonsense-mediated decay (NMD), non-stop decay (NSD) and no-go decay (NGD) – operate while the mRNA is translated. They ensure that only proper mRNA can engage in more than one translation cycle and only intact, functional proteins can accumulate. Thus the integrity of the transcriptome and the proteome relies on the action of these QC systems. Emerging evidence points out that NMD not only controls the accumulation of faulty messages, but it has a regulatory role in gene expression, especially under pathogen infection in plants. There is a high possibility that the other two systems NSD and NGD also have a regulatory role in the accumulation of endogenous transcripts as well as in the coordination of defense against pathogen infections. The possible role of translation-coupled QC systems in defense highlights their ability to became new sources of resistance in breeding.
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