Clinical paratuberculosis (Johne’s disease) and chronic mastitis can be successfully treated with a novel therapy in dairy cows – a case report
Keywords:
Johne’s disease, Mycobacterium avium subspecies paratuberculosis, mastitis, herbal therapy, anti-inflammatory effectAbstract
Paratuberculosis, a thus far untreatable infectious disease of ruminants has been known for more than a hundred years. While subclinical infections cause severe financial losses, the development of clinical symptoms results in inevitable premature death of the animals. Its causative agent, Mycobacterium avium subspecies paratuberculosis (MAP) is distributed worldwide, however, due to its limited diagnosis at subclinical stage, controling the spread of the disease is difficult. It has a significant impact on milk production, fertility and increased incidence of mastitis. Mastitis is the most costly disease of dairy farms, as it can effect as high as 40% of the herds. In this report we present a new approach to therapy, in wich, without any application of antibiotics or steroids, using exclusively natural herbal remedies, we have been able successfully to cure a five and half year old, naturally-infected dairy cow - manifesting the clinical signs and symptoms of paratuberculosis and chronic mastitis - within six weeks. The MAP negative fecal culture supports the complete cure. To our knowledge the therapy applied by us is the first proven remedy for curing clinical paratuberculosis.
References
Barta, Z., Csipo, I., Mekkel, G., Zeher, M., Majoros, L. (2004): Seroprevalence of Mycobacterium paratuberculosis in patients with Crohn's Disease. J Clin Microbiol., 42(11) 5432; author reply 5432–5433. https://doi.org/10.1128/JCM.42.11.5432-5433.2004
Barta, Z., Mekkel, G., Csípo, I., Tóth, L., Szakáll, S., Szabó, G.G., Bakó, G., Szegedi, G., Zeher, M. (2005a) Microscopic colitis: a retrospective study of clinical presentation in 53 patients. World J Gastroenterol., 11(9) 1351–1355. https://doi.org/10.3748/wjg.v11.i9.1351
Barta, Z., Szabó, G. G, Zeher, M., Szegedi, G. (2005b): Microscopic colitis. Orv. Hetil., 146(37) 1913–1917.
Barta, Zs. (2005): Nem specifikus gyulladásos bélbetegségek klinikai, immunológiai és terápiás vonatkozásai. Egyetemi doktori (PhD) értekezés. Debrecen
Baumgartner, W., Khol, J. L. (2008): Paratuberculosis – potentials and limits of control programs. XXV Jubilee World Buiatrics Congress, July 6–11, Budapest, Hungary, 130. 7–10.
Bernstein, C. N., Blanchard, J. F., Rawsthorne, P., Collins, M. T. (2004): Population-based case control study of seroprevalence of Mycobacterium paratuberculosis in patients with Crohn’s disease and ulcerative colitis. J. Clin. Microbiol., 42(3) 1129–1135. https://doi.org/10.1128/JCM.42.3.1129-1135.2004
Collins, M. T. (2004): Update on paratuberculosis: 3. Control and zoonotic potential. Ir. Vet. J., 57. 49–52.
Council for Agricultural Science and Technology (2001): Johne’s Disease in Cattle. Issue Paper No. 17 (May 2001). Ames, IA: Council for Agricultural Science and Technology.
Crohn's and Colitis UK (2003): Report of the NACC Expert Review Group into the evidence linking Mycobacterium paratuberculosis (MAP) and Crohn’s Disease, December 2003. Available at: http://www.nacc.org.uk/downloads/MAPver9.pdf, last accessed 07 December 2010.
DEFRA. (2009): Department for Environment, Food and Rural Affairs. Section 1: Report on the analysis of the study on the prevalence of Johne’s disease in the UK dairy herd.
Donaghy, J. A., Totton, N. L., Rowe, M. T. (2004): Persistence of Mycobacterium paratuberculosis during manufacture and ripening of Cheddar cheese. Appl. Environ. Microbiol., 70(8) 4899–4905. https://doi.org/10.1128/AEM.70.8.4899-4905.2004
Epinfo (2002): Epidemológiai Információs Hetilap, 9(2) 4.
Grant, I. R. (2005): Zoonotic potential of Mycobacterium avium ssp. paratuberculosis: the current position. Journal of Applied Microbiology, 98(6) 1282–1293. https://doi.org/10.1111/j.1365-2672.2005.02598.x
Hillerton, J. E., Berry, E. A., (2005): Treating mastitis in the cow – a tradition or an archaism. J. Appl. Microbiol., 98(6) 1250–1255. https://doi.org/10.1111/j.1365-2672.2005.02649.x
Juhász-Kaszanyitzky, E., Jánosi, S., Somogyi, P., Dán, A., van der Graaf-van Bloois, L., van Duijkeren, E., Wagenaar, J. A. (2007): MRSA transmission between cows and humans. Emerg Infect Dis., 13(4) 630–632. https://doi.org/10.3201/eid1304.060833
Körmendy, B., Szilágyi, M., Tuboly, S., Nagy, Gy. (1990): Some Diagnostic Features of the Pathogenesis of Bovine Paratuberculosis (Johne's Disease) and Serum Biochemical Changes after Oral Reinfection. J. Vet. Med. B, 37(1–10) 229–235. https://doi.org/10.1111/j.1439-0450.1990.tb01051.x
Körmendy, B. (1994): The effect of vaccination on the prevalence of paratuberculosis in large dairy herds. Vet. Microbiol., 41(1–2) 117–125. https://doi.org/10.1016/0378-1135(94)90141-4
Krishnan, M. Y., Manning, E. J. B., Collins, M. T. (2009): Comparison of three methods for susceptibility testing of Mycobacterium avium subsp. paratuberculosis to 11 antimicrobial drugs. J. Antimicrobial. Chemotherapy, 64(2) 310–316. https://doi.org/10.1093/jac/dkp184
Labro, M. T., Abdelghaffar, H. (2001): Immunomodulation by macrolide antibiotics. J. Chemother. 13(1) 3–8. https://doi.org/10.1179/joc.2001.13.1.3
Manning, E. J. B., Collins, M. T. (2001): Mycobacterium avium subsp. paratuberculosis: Pathogen, pathogenesis and diagnosis. In Mycobacterial infections in domestic and wild animals, E. J. B. Manning and M. T. Collins (eds.). Revue Scientifique et Technique Office International des E´ pizooties, 20(1) 133–150. https://doi.org/10.20506/rst.20.1.1275
OIE MM 2004 2. 2. 6. B. 2. b : Manual of Diagnostic Tests and Vaccines for Terrestrial Animals Chapter 2.2.6. Paratuberculosis (Johne's disease)
O’Reilly, C. E., O’Connor, L., Anderson, W., Harvey, P., Grant, I. R., Donaghy, J., Rowe, M., O’Mahony, P. (2004): Surveillance of bulk raw and commercially pasteurised cows_ milk from approved Irish liquid milk pasteurising plants for Mycobacterium paratuberculosis. Appl Environ Microbiol., 70(9) 5138–5144. https://doi.org/10.1128/AEM.70.9.5138-5144.2004
O’Rourke, D. (2009): Nutrition and udder health in dairy cows: a review. Irish Vet. J., 62(Suppl. 4) 15–20. https://doi.org/10.1186/2046-0481-62-S4-S15
Rossiter, C. J., Henning, W. R. (2001): Isolation of Mycobacterium paratuberculosis from thin market cows at slaughter. J. Anim. Sci., 79. 113.
Ryan, P., Bennett, M. W., Aarons, S., Lee, G., Collins, J. K., O'Sullivan, G. C., O'Connell, J., Shanahan, F. (2002): PCR detection of Mycobacterium paratuberculosis in Crohn's disease granulomas isolated by laser capture microdissection. Gut., 51(5) 665–670. https://doi.org/10.1136/gut.51.5.665
St. Jean, G. (1996): Treatment of clinical paratuberculosis in cattle. Veterinary Clinics of North America – Food Animal Practice, 12(2) 417–430. https://doi.org/10.1016/S0749-0720(15)30414-X
Streeter, R. N., Hoffsis, G. F., Bech-Nielsen, S., Shulaw, W. P., Rings, M. (1995): Isolation of Mycobacterium paratuberculosis from colostrum and milk of subclinically infected cows. Am J Vet Res., 56(10) 1322– 1324. https://doi.org/10.2460/ajvr.1995.56.10.1322
Szilágyi, M., Körmendy, B., Suri, A., Tuboly, S., Nagy, G. (1989): Experimental paratuberculosis (Johne's disease) – studies on biochemical parameters in cattle. Archiv für experimentelle Veterinärmedizin. 43(3) 463–470.
Tiwari, A., VanLeeuwen, J. A., Dohoo, I. R., Keefe, G. P., Weersink, A. (2008): Estimate of the direct production losses in Canadian dairy herds with subclinical Mycobacterium avium subspecies paratuberculosis infection. Can. Vet. J., 49(6) 569–576.
Tiwari, A., VanLeeuwen, J, A., McKenna, S. L., Keefe, G. P., Barkema, H. W. (2006): Johne’s disease in Canada Part I: Clinical symptoms, pathophysiology, diagnosis, and prevalence in dairy herds. Can. Vet. J., 47. 874–882.
Tuboly, S., Kovács, Á., Lami, E., Nagy, Gy. (2005): Az ember Crohn- és a szarvasmarha Johne-betegsége (paratuberculosisa) közötti összefüggések. Magyar Állatorvosok Lapja, 127(2) 106–112.
Watts, J. L. (1988): Etiological agents of bovine mastitis. Vet Microbiol., 16(1) 41–66. https://doi.org/10.1016/0378-1135(88)90126-5
Whitlock, R. H., Buergelt, C. (1996): Preclinical and clinical manifestations of paratuberculosis (including pathology). Vet. Clin. North. Am. Food. Anim. Pract., 12(2) 345–356. https://doi.org/10.1016/S0749-0720(15)30410-2
Wilson, D. J., Rossiter, C., Han, H. R., Sears, P. M. (1993): Association of Mycobacterium paratuberculosis infection with reduced mastitis, but with decreased milk production and increased cull rate in clinically normal dairy cows. Am. J. Vet. Res., 54(11) 1851–1857. https://doi.org/10.2460/ajvr.1993.54.11.1851
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